The Orfeo ToolBox (OTB) is an open-source C++ library for processing of remote sensing image, and it is shipped with Monteverdi, an end-users oriented software for for classical remote sensing tasks. With the recent release of OTB version 5.4, I decided to make this brief post on how to get it running on OSX. I’m running El Capitan (10.11), but it should be the same for other versions.